Long-term intensive insulin therapy for Japanese patients with type 2 diabetes mellitus

Intern Med. 2008;47(24):2109-15. doi: 10.2169/internalmedicine.47.1353. Epub 2008 Dec 15.

Abstract

Objective: To determine the clinical usefulness of long-term intensive insulin therapy in Japanese patients with type 2 diabetes.

Patients and methods: Various clinical indicators and potential of withdrawal from insulin therapy were investigated in 20 type 2 diabetic patients receiving treatment in the outpatient clinic over a period of 8 years after starting intensive insulin therapy between April 1997 and March 1999.

Results: The mean glycated hemoglobin (HbA1c) was approximately 6.5%, and there was no significant increase in insulin dose over a period of 8 years after commencement of intensive insulin therapy. Withdrawal from insulin therapy could be sustained in previously untreated patients.

Conclusion: Our results indicated the clinical usefulness of intensive insulin therapy over the long term in Japanese patients with type 2 diabetes and that such therapy could be especially useful for previously untreated patients.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Asian People*
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / complications
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Dose-Response Relationship, Drug
  • Female
  • Follow-Up Studies
  • Humans
  • Insulin / administration & dosage*
  • Insulin / blood
  • Male
  • Middle Aged
  • Time Factors

Substances

  • Insulin