Role of acidosis, NMDA receptors, and acid-sensitive ion channel 1a (ASIC1a) in neuronal death induced by ischemia

Biochemistry (Mosc). 2008 Nov;73(11):1171-5. doi: 10.1134/s0006297908110011.

Abstract

This review collects data on the influence of intracellular and extracellular acidosis on neuronal viability and the effect of acidosis on neuronal damage progressing under brain ischemia/hypoxia. Particular attention is devoted to the involvement of ionotropic glutamic receptors and acid-sensitive ion channel 1a in these processes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acid Sensing Ion Channels
  • Acidosis / metabolism*
  • Acidosis / physiopathology
  • Animals
  • Brain Ischemia / metabolism*
  • Brain Ischemia / physiopathology
  • Cell Death
  • Glutamic Acid / metabolism
  • Glutamic Acid / toxicity
  • Humans
  • Hypoxia / metabolism
  • Hypoxia / physiopathology
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / metabolism*
  • Neurons / cytology
  • Neurons / drug effects
  • Neurons / physiology*
  • Receptors, N-Methyl-D-Aspartate / genetics
  • Receptors, N-Methyl-D-Aspartate / metabolism*
  • Sodium Channels / genetics
  • Sodium Channels / metabolism*

Substances

  • ASIC1 protein, human
  • Acid Sensing Ion Channels
  • Nerve Tissue Proteins
  • Receptors, N-Methyl-D-Aspartate
  • Sodium Channels
  • Glutamic Acid