Abstract
We report the clinical course of a child with precursor B-cell acute lymphoblastic leukemia who developed fever, hepatosplenomegaly, and refractory thrombocytopenia after initiation of chemotherapy. Bone marrow aspiration on Day 8 of induction showed new onset of hemophagocytosis and he met clinical, laboratory, and histopathologic criteria for hemophagocytic lymphohistiocytosis. His symptoms improved significantly after an increased dosage of steroids.
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / adverse effects*
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Asparaginase / administration & dosage
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Bone Marrow / pathology
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Child, Preschool
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Dexamethasone / administration & dosage
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Fever / etiology
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Hepatomegaly / chemically induced
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Humans
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Lymphohistiocytosis, Hemophagocytic / chemically induced*
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Lymphohistiocytosis, Hemophagocytic / drug therapy
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Male
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Polyethylene Glycols / administration & dosage
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Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
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Remission Induction
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Splenomegaly / chemically induced
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Thrombocytopenia / chemically induced
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Vincristine / administration & dosage
Substances
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Polyethylene Glycols
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Vincristine
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pegaspargase
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Dexamethasone
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Asparaginase