Discovery of novel small molecule cell type-specific enhancers of NF-kappaB nuclear translocation

Bioorg Med Chem Lett. 2009 Feb 15;19(4):1191-4. doi: 10.1016/j.bmcl.2008.12.086. Epub 2008 Dec 25.

Abstract

An IKKbeta inhibitor reported to block NF-kappaB transcriptional activities in Jurkat T cells, was found to enhance NF-kappaB translocation in HUVEC cells. These studies suggested a noncanonical NF-kappaB signaling pathway independent of IKKbeta in HUVEC cells.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Combinatorial Chemistry Techniques
  • Humans
  • Jurkat Cells
  • Leupeptins / chemistry
  • Leupeptins / pharmacology
  • Molecular Structure
  • NF-kappa B / drug effects
  • NF-kappa B / metabolism*
  • Nitriles / chemistry
  • Nitriles / pharmacology
  • Quinazolines / chemical synthesis*
  • Quinazolines / chemistry
  • Quinazolines / pharmacology*
  • Sulfones / chemistry
  • Sulfones / pharmacology
  • Sulfoxides / chemistry
  • Sulfoxides / pharmacology
  • Tetrazoles / chemistry
  • Tetrazoles / pharmacology

Substances

  • 3-(4-methylphenylsulfonyl)-2-propenenitrile
  • Leupeptins
  • NF-kappa B
  • Nitriles
  • Quinazolines
  • Ro 106-9920
  • Sulfones
  • Sulfoxides
  • Tetrazoles
  • benzyloxycarbonylleucyl-leucyl-leucine aldehyde