A lysine walk to high relaxivity collagen-targeted MRI contrast agents

Chem Commun (Camb). 2009 Jan 28:(4):430-2. doi: 10.1039/b819098d. Epub 2008 Dec 10.

Authors

Peter Caravan¹, Biplab Das, Qing Deng, Stéphane Dumas, Vincent Jacques, Steffi K Koerner, Andrew Kolodziej, Richard J Looby, Wei-Chuan Sun, Zhaoda Zhang

Affiliation

¹ A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth St, Suite 2301, Charlestown, MA 02129, USA. caravan@nmr.mgh.harvard.edu

PMID: 19137175
DOI: 10.1039/b819098d

Abstract

A strategy for preparing peptide-based magnetic resonance contrast agents with multiple gadolinium chelates is described.

MeSH terms

Amino Acid Sequence
Chromatography, High Pressure Liquid
Collagen / metabolism*
Contrast Media / chemical synthesis*
Gadolinium DTPA / chemistry
Lysine / chemistry*
Magnetic Resonance Imaging*
Molecular Sequence Data
Structure-Activity Relationship

Substances

Contrast Media
Collagen
Gadolinium DTPA
Lysine