A systems approach to analysis of molecular complexity in breast cancer

Clin Cancer Res. 2009 Jan 15;15(2):417-9. doi: 10.1158/1078-0432.CCR-08-2620.

Abstract

In this issue of Clinical Cancer Research, Andre et al. apply high-resolution arrays to elucidate copy number anomalies in breast cancer. They identify distinct copy number anomaly patterns in different breast cancer subtypes that implicate a number of genes as potential therapeutic targets and as potential markers of therapy responsiveness.

Publication types

  • Comment

MeSH terms

  • Algorithms
  • Biomarkers, Tumor / metabolism
  • Breast Neoplasms / diagnosis*
  • Breast Neoplasms / pathology*
  • Computational Biology / methods
  • Gene Expression Profiling
  • Humans
  • Medical Oncology / methods
  • Models, Biological
  • Nucleic Acid Hybridization
  • Oligonucleotide Array Sequence Analysis
  • Phosphatidylinositol 3-Kinases / metabolism
  • Proteomics / methods
  • Systems Biology

Substances

  • Biomarkers, Tumor
  • Phosphatidylinositol 3-Kinases