Abstract
Can dendrites grow in mature cortex? We used chronic in vivo imaging to follow pyramidal neurons before and after cortical deletion of the Pten tumor suppressor gene in mature mice. We found that Pten/mTOR signaling uniquely regulates the growth of layer 2/3 apical dendrites; no effects of gene deletion were observed on basal dendrites of these pyramidal neurons or along layer 5 apical dendrites.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Age Factors
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Animals
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Antibiotics, Antineoplastic / pharmacology
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Carrier Proteins / metabolism*
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Cerebral Cortex / cytology*
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Cerebral Cortex / growth & development
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Cerebral Cortex / physiology
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Dendrites / physiology*
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Gene Expression Regulation, Developmental
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Humans
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Mice
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PTEN Phosphohydrolase / genetics*
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PTEN Phosphohydrolase / metabolism
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Phosphotransferases (Alcohol Group Acceptor) / metabolism*
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Pyramidal Cells / physiology*
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Pyramidal Cells / ultrastructure
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Signal Transduction / drug effects
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Signal Transduction / physiology
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Sirolimus / pharmacology
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TOR Serine-Threonine Kinases
Substances
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Antibiotics, Antineoplastic
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Carrier Proteins
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Phosphotransferases (Alcohol Group Acceptor)
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MTOR protein, human
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mTOR protein, mouse
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TOR Serine-Threonine Kinases
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PTEN Phosphohydrolase
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Pten protein, mouse
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Sirolimus