Correlation between kinematics and morphological characteristics of lumbar spine was studied in subjects with varying bone mineral density. Effect of morphological characteristics and bone mineral density on the lumbar spine movement was investigated. Morphology parameters were measured from radiographs and a high-frequency motion tracking device were employed to detect surface movement of lumbar spine. Multiple regression analysis identified factors influencing lumbar kinematics while ANOVA examined differences in morphology with normal bone mineral density, osteopenia and osteoporosis. The results show that morphological characteristics, such as wedging deformity, are indeed influential to the kinematics. Related to our previous report, abnormal lumbar kinematic pattern in the subjects with osteoporosis, this study shows although morphological characteristics were found significantly different among normal, osteopenia, and osteoporosis subjects, the change in lumbar kinematic pattern could not be fully explained by the altered vertebral or disc morphology.