A controlled clinical interventional trial comparing 2% chloroprocaine-bupivicaine versus 2% lidocaine-bupivicaine for retrobulbar anesthesia in scleral buckling surgery

Can J Ophthalmol. 2009 Feb;44(1):83-7. doi: 10.3129/i08-166.

Abstract

Objective: We undertook this prospective study to compare the relative effectiveness of a bupivicaine mixture with either lidocaine or chloroprocaine for retrobulbar anesthesia in scleral buckling surgery, since chloroprocaine, in some types of nonocular nerve block anesthesia, has been demonstrated to be a more effective nerve block anesthetic.

Design: This prospective, randomized, double-blind, controlled, clinical, unicentre, interventional trial compared mixtures of lidocaine-bupivacaine with chloroprocaine-bupivacaine in scleral buckling surgery performed by 1 surgeon during a 12-month period.

Participants: A total of 136 patients who underwent scleral buckling surgery constituted the cases studied.

Methods: A total of 31 variables comprising surgical, anesthetic, and patient-centered data were analyzed to determine which drug combination was more efficacious.

Results: No statistically significant differences were found between chloroprocaine and lidocaine mixtures for retrobulbar anesthesia in scleral buckling surgery from the point of view of the surgeon, anesthetist, or patient.

Conclusions: We found no difference in effectiveness for bupivicaine mixed with either lidocaine or chloroprocaine for retrobulbar anesthesia in scleral buckling surgery. Surgeon, anesthetist, and patient-centered data showed no differences in any of the measures studied.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anesthesia, Local / methods*
  • Anesthetics, Combined / administration & dosage*
  • Anesthetics, Local / administration & dosage*
  • Bupivacaine / administration & dosage*
  • Double-Blind Method
  • Female
  • Humans
  • Lidocaine / administration & dosage*
  • Male
  • Middle Aged
  • Orbit
  • Pain Measurement
  • Pain, Postoperative / diagnosis
  • Patient Satisfaction
  • Procaine / administration & dosage
  • Procaine / analogs & derivatives*
  • Prospective Studies
  • Retinal Detachment / surgery
  • Scleral Buckling*
  • Treatment Outcome
  • Young Adult

Substances

  • Anesthetics, Combined
  • Anesthetics, Local
  • Procaine
  • chloroprocaine
  • Lidocaine
  • Bupivacaine