Objective: To investigate the main risk factors related to the incidence of perinatal congenital heart disease (CHD) in Chinese people.
Methods: Results on the risk factors of CHD in 12 papers were analyzed by Meta-analysis method. The cumulative cases and controls were 3436 and 3976, respectively. The calculation methods of the combined odds ratio (OR) and 95% confidence interval (CI) were determined according to the homogeneity test.
Results: The pooled OR values of single-factor-analysis were as follows: spiritual stimulus (4.55), maternal exposures to pesticides (4.85), negative life events (5.39) during pregnancy, cold (3.18) during early pregnancy, exposure to chemical toxic substances before pregnancy. The pooled OR values of multiple-factor analysis were as follows: spiritual stimulus (4.08), exposure to chemical toxic substances (3.54), cold with fever (5.00) during pregnancy.
Conclusion: The main factors influencing the incidence of CHD in Chinese people were current spiritual stimulus, exposure to chemical toxic substances or pesticides, negative life events during pregnancy, cold or fever during early pregnancy, exposure to chemical toxic substances before pregnancy.