Condyloma acuminatum is a sexually transmitted disease caused by human papillomavirus infection, especially HPV DNA types 6 and 11. Its appearance is distinctively papillary and it can be diagnosed by careful observation of its particular appearance. The treatment for condyloma acuminatum is generally classified into surgical and medical therapies. In Japan, imiquimod has finally been approved and can be prescribed in the clinical situation. Treatment with 5% imiquimod cream is highly effective and noninvasive compared with surgical therapy. We anticipate that imiquimod will contribute to efficient control of the disease in the future.