Coronary arteries of anomalous origin are uncommon and all three coronary arteries arising from a single sinus of Valsalva is very rare. Percutaneous coronary intervention of such arteries is technically difficult and challenging. We report the case of a patient with all three coronary arteries arising from the right sinus of Valsalva who presented with acute coronary syndrome. Coronary angiography showed significant stenosis of the left circumflex and left anterior descending coronary arteries followed by successful angioplasty and stenting of these arteries.