Abstract
In 2007, Clostridium difficile polymerase chain reaction (PCR) ribotype 027 emerged in Germany. We conducted a hospital-based case-control study to identify specific risk factors for infection with this strain. Logistic regression analysis involving 15 case patients and 31 control patients revealed that exposure to fluoroquinolones (matched odds ratio, 36.2; P < .01) or cephalosporins (matched odds ratio, 19.1; P < .01) was independently related to C. difficile PCR ribotype 027 infection.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Anti-Bacterial Agents / adverse effects*
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Anti-Bacterial Agents / therapeutic use
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Case-Control Studies
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Cephalosporins / adverse effects
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Cephalosporins / therapeutic use
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Clostridioides difficile / physiology
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Clostridium Infections / drug therapy
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Clostridium Infections / epidemiology*
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Clostridium Infections / mortality
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Cross Infection / drug therapy
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Cross Infection / epidemiology*
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Cross Infection / microbiology
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Female
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Fluoroquinolones / adverse effects
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Fluoroquinolones / therapeutic use
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Germany / epidemiology
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Hospitals, Teaching / statistics & numerical data
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Humans
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Male
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Middle Aged
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Polymerase Chain Reaction
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Retrospective Studies
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Ribotyping
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Risk Factors
Substances
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Anti-Bacterial Agents
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Cephalosporins
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Fluoroquinolones