Synaptic vesicle endocytosis: get two for the price of one?

Neuron. 2009 Feb 12;61(3):333-4. doi: 10.1016/j.neuron.2009.01.022.

Abstract

Tight coupling between synaptic vesicle exocytosis and endocytosis is critical for the maintenance of neurotransmission. In this issue of Neuron, Zhu et al. reveal a surprising facet of this coupling by showing that, at low frequencies, fusion of a single vesicle leads to retrieval of two vesicles with dissimilar attributes.

Publication types

  • Comment

MeSH terms

  • Animals
  • Central Nervous System / metabolism*
  • Central Nervous System / ultrastructure
  • Endocytosis / physiology*
  • Fluorescent Dyes
  • Humans
  • Membrane Fusion / physiology
  • Nerve Tissue Proteins / metabolism
  • Presynaptic Terminals / metabolism*
  • Presynaptic Terminals / ultrastructure
  • Staining and Labeling / methods
  • Synaptic Transmission / physiology*
  • Synaptic Vesicles / metabolism*
  • Synaptic Vesicles / ultrastructure

Substances

  • Fluorescent Dyes
  • Nerve Tissue Proteins