Binding properties of monoclonal antibodies to rabies virus

Microbiologica. 1991 Jul;14(3):205-11.

Abstract

The monoclonal antibodies (mAbs) obtained by immunizing mice with a tetradecapeptide corresponding to the 190-203 region of rabies virus glycoprotein, involved in binding to the acetylcholine receptor (AchR), displayed different specificities to different rabies virus strains. These mAbs, when used in immunofluorescence tests, allowed differentiation of wild rabies viruses from the attenuated ones.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antibodies, Monoclonal / immunology*
  • Antibodies, Viral / immunology
  • Antibody Specificity
  • Enzyme-Linked Immunosorbent Assay
  • Fluorescent Antibody Technique
  • Mice
  • Molecular Sequence Data
  • Rabies Vaccines / immunology
  • Rabies virus / immunology*
  • Vaccines, Attenuated / immunology

Substances

  • Antibodies, Monoclonal
  • Antibodies, Viral
  • Rabies Vaccines
  • Vaccines, Attenuated