Identification of the first fluorescent alpha-amidoboronic acids that change fluorescent properties upon sugar binding

Bioorg Med Chem Lett. 2009 Mar 15;19(6):1596-9. doi: 10.1016/j.bmcl.2009.02.011. Epub 2009 Feb 8.

Abstract

The first amidoboronic acids were identified that show significant fluorescent property changes upon binding with various carbohydrates.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Boronic Acids / chemistry*
  • Carbohydrates / chemistry
  • Chemistry, Organic / methods
  • Chemistry, Pharmaceutical / methods
  • Drug Design
  • Fluorescent Dyes / chemistry*
  • Kinetics
  • Models, Chemical
  • Models, Molecular
  • Molecular Structure
  • Protein Binding
  • Spectrometry, Fluorescence

Substances

  • Boronic Acids
  • Carbohydrates
  • Fluorescent Dyes