Rhabdomyolysis caused by co-medication with simvastatin and clarithromycin

J Neurol. 2009 Jul;256(7):1182-3. doi: 10.1007/s00415-009-5078-6. Epub 2009 Mar 1.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Aged
  • Anti-Bacterial Agents / adverse effects*
  • Clarithromycin / adverse effects*
  • Contraindications
  • Cytochrome P-450 CYP3A Inhibitors
  • Dose-Response Relationship, Drug
  • Drug Interactions
  • Energy Metabolism / drug effects
  • Energy Metabolism / physiology
  • Female
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects*
  • Iatrogenic Disease / prevention & control
  • Muscle Weakness / chemically induced
  • Muscle Weakness / metabolism
  • Muscle Weakness / physiopathology
  • Muscle, Skeletal / drug effects
  • Muscle, Skeletal / metabolism
  • Muscle, Skeletal / physiopathology
  • Rhabdomyolysis / chemically induced*
  • Risk Factors
  • Simvastatin / adverse effects*

Substances

  • Anti-Bacterial Agents
  • Cytochrome P-450 CYP3A Inhibitors
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Simvastatin
  • Clarithromycin