The response of left ventricular (LV) geometry to altered loading conditions after mitral valvuloplasty has been incompletely described. Therefore, 15 patients with rheumatic mitral stenosis were studied using quantitative 2-dimensional echocardiography a mean of 1 +/- 2 months before and 11 +/- 5 months after percutaneous balloon mitral valvuloplasty. Mitral valve area (Gorlin) increased in all patients, from 1.0 +/- 0.3 to 1.9 +/- 0.5 cm2 (p less than 0.01). Mitral regurgitation (1+/4+) developed in 3 patients, and increased by 1 grade in 1 patient as a consequence of mitral valvuloplasty. After valvuloplasty, there were significant increases in LV end-diastolic volume (69 +/- 22 to 82 +/- 26 ml, p less than 0.01), stroke volume (34 +/- 13 to 46 +/- 19 ml, p less than 0.05) and mass (181 +/- 46 to 200 +/- 42 ml, p less than 0.005). LV end-systolic volume and ejection fraction did not change significantly. LV mass-to-volume ratio was unchanged (5.6 +/- 1.5 to 5.8 +/- 1.4 g/ml, p = not significant). Quantitatively similar results were obtained when these changes were indexed to body surface area. Thus, successful mitral valvuloplasty was associated with significant increases in LV end-diastolic volume and mass. These findings suggest that increased preload may be a stimulus to myocardial growth.