Abstract
Type 17 Th (Th17) cells have been identified as a distinct population of CD4(+) effector T cells different from Th1 and Th2 cells. While the pre-eminent cytokine of Th1 cells is IFN-gamma and that of Th2 cells is IL-4, the distinctive cytokine of Th17 cells is IL-17A. However, although murine and human Th1 and Th2 cells exhibit strong similarities, human and murine Th17 cells seem to differ in several aspects.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Humans
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Interleukin-17 / immunology*
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Interleukin-17 / metabolism
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Lectins, C-Type / immunology
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Lectins, C-Type / metabolism
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Mice
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NK Cell Lectin-Like Receptor Subfamily B / immunology
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NK Cell Lectin-Like Receptor Subfamily B / metabolism
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Receptors, Cell Surface / immunology
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Receptors, Cell Surface / metabolism
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T-Lymphocytes, Helper-Inducer / immunology*
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T-Lymphocytes, Helper-Inducer / metabolism
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Th1 Cells / immunology*
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Th1 Cells / metabolism
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Th2 Cells / immunology*
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Th2 Cells / metabolism
Substances
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CLEC2D protein, human
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Interleukin-17
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Lectins, C-Type
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NK Cell Lectin-Like Receptor Subfamily B
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Receptors, Cell Surface