Structural requirements of the Pseudomonas quinolone signal for membrane vesicle stimulation

J Bacteriol. 2009 May;191(10):3411-4. doi: 10.1128/JB.00052-09. Epub 2009 Mar 13.

Abstract

Pseudomonas aeruginosa produces the quorum signal 2-heptyl-3-hydroxy-4-quinolone (Pseudomonas quinolone signal), which is important for stimulating outer membrane vesicle (MV) formation. Here we describe the importance of the 3-hydroxyl and 2-alkyl chain for MV production and the length of the 2-alkyl chain for association with MVs.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Lipopolysaccharides / chemistry
  • Lipopolysaccharides / metabolism
  • Models, Molecular
  • Pseudomonas aeruginosa / metabolism*
  • Quinolones / chemistry*
  • Quinolones / metabolism*
  • Secretory Vesicles / metabolism*
  • Signal Transduction
  • Structure-Activity Relationship

Substances

  • 2-heptyl-3-hydroxy-4-quinolone
  • Lipopolysaccharides
  • Quinolones