Pediatric Atorvastatin in Diabetes Trial (PADIT): a pilot study to determine the effect of atorvastatin on arterial stiffness and endothelial function in children with type 1 diabetes mellitus

J Pediatr Endocrinol Metab. 2009 Jan;22(1):65-8. doi: 10.1515/jpem.2009.22.1.65.

Abstract

Fifty-one children with type 1 diabetes mellitus (DM1) participated in a double blinded, randomized, cross-over pilot study to determine whether 12 weeks of daily atorvastatin (20 mg daily) would reduce arterial stiffness and improve endothelial function. Secondary analysis demonstrated potential reduction of arterial stiffness following atorvastatin therapy (p = 0.06). Additional long-term prospective studies with larger numbers of patients are needed.

Trial registration: ClinicalTrials.gov NCT00130481.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Anticholesteremic Agents / pharmacology
  • Anticholesteremic Agents / therapeutic use
  • Atorvastatin
  • Child
  • Cross-Over Studies
  • Diabetes Mellitus, Type 1 / drug therapy*
  • Diabetes Mellitus, Type 1 / physiopathology
  • Diabetic Angiopathies / prevention & control
  • Double-Blind Method
  • Endothelium, Vascular / drug effects*
  • Endothelium, Vascular / physiopathology
  • Female
  • Heptanoic Acids / pharmacology*
  • Heptanoic Acids / therapeutic use*
  • Humans
  • Male
  • Patient Compliance
  • Peripheral Vascular Diseases / prevention & control
  • Pilot Projects
  • Placebos
  • Pyrroles / pharmacology*
  • Pyrroles / therapeutic use*
  • Radial Artery / drug effects*
  • Radial Artery / physiopathology
  • Vascular Resistance / drug effects*
  • Young Adult

Substances

  • Anticholesteremic Agents
  • Heptanoic Acids
  • Placebos
  • Pyrroles
  • Atorvastatin

Associated data

  • ClinicalTrials.gov/NCT00130481