Varicella as a trigger of atypical haemolytic uraemic syndrome associated with complement dysfunction: two cases

Nephrol Dial Transplant. 2009 Sep;24(9):2752-4. doi: 10.1093/ndt/gfp166. Epub 2009 Apr 17.

Abstract

We report two cases of children who presented with haemolytic uraemic syndrome following varicella infection. One of them had a membrane cofactor protein mutation, and the other had anti-factor H antibodies. These observations show that infectious agents such as varicella-zoster virus may be the trigger of haemolytic uraemic syndrome in patients with complement dysregulation.

Publication types

  • Case Reports

MeSH terms

  • Autoantibodies / blood*
  • Chickenpox / complications*
  • Chickenpox / genetics
  • Chickenpox / immunology*
  • Child, Preschool
  • Complement Factor H / antagonists & inhibitors*
  • Complement Factor H / immunology
  • Female
  • Hemolytic-Uremic Syndrome / etiology*
  • Hemolytic-Uremic Syndrome / genetics
  • Hemolytic-Uremic Syndrome / immunology*
  • Heterozygote
  • Humans
  • Male
  • Membrane Cofactor Protein / deficiency*
  • Membrane Cofactor Protein / genetics
  • Point Mutation
  • Time Factors

Substances

  • Autoantibodies
  • CD46 protein, human
  • Membrane Cofactor Protein
  • Complement Factor H