A population study of a mutation allele associated with cone-rod dystrophy in the standard wire-haired dachshund

Anim Genet. 2009 Aug;40(4):572-4. doi: 10.1111/j.1365-2052.2009.01877.x. Epub 2009 Mar 20.

Abstract

Cone-rod dystrophy in the standard wire-haired dachshund (SWHD) is inherited as a simple autosomal recessive trait and the recently discovered mutation is widespread within the SWHD population in Norway and other Scandinavian countries. The gene frequency was estimated to be 4.8%. On the basis of the assumption that the size of the ancestral haplotype around a mutation is inversely correlated with the number of generations since the mutation arose, we have found that the mutation is of a relatively recent origin. The conserved haplotype was found to be 8 Mb in size and therefore we estimate that the mutation arose roughly eight generations (approximately 37 years) ago. This indicates that the mutation arose after breed separation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Animals
  • Dog Diseases / genetics*
  • Dogs / genetics*
  • Dogs / physiology
  • Gene Frequency
  • Linkage Disequilibrium
  • Mutation*
  • Pedigree
  • Retinitis Pigmentosa / genetics
  • Retinitis Pigmentosa / veterinary*