Abstract
The epidemiology of Burkholderia infection in persons with chronic granulomatous disease is poorly understood. We used species-specific polymerase chain reaction-based assays and genotyping analyses to identify 32 strains representing 9 Burkholderia species among 50 isolates recovered from 18 patients with chronic granulomatous disease. We found that recurrent pulmonary infection with distinct Burkholderia strains is common in chronic granulomatous disease.
Publication types
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Case Reports
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Research Support, N.I.H., Extramural
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Research Support, N.I.H., Intramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Burkholderia / classification
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Burkholderia / genetics
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Burkholderia / isolation & purification*
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Burkholderia Infections / epidemiology*
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Burkholderia Infections / microbiology
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DNA, Bacterial / genetics
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Genotype
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Granulomatous Disease, Chronic / complications*
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Humans
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Pneumonia, Bacterial / epidemiology*
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Pneumonia, Bacterial / microbiology
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Polymerase Chain Reaction / methods
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Recurrence