Abstract
Suppression of oncogenic Wnt-mediated signaling holds promise as an anti-cancer therapeutic strategy. We previously reported a novel class of small molecules (IWR-1/2, inhibitors of Wnt response) that antagonize Wnt signaling by stabilizing the Axin destruction complex. Herein, we present the results of structure-activity relationship studies of these compounds.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Aminoquinolines / chemistry*
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Animals
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Axin Protein
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Imides / chemistry*
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Repressor Proteins / metabolism
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Signal Transduction
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Structure-Activity Relationship
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Tail
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Wnt Proteins / antagonists & inhibitors*
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Wnt Proteins / metabolism
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Zebrafish / metabolism
Substances
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Aminoquinolines
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Axin Protein
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Imides
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Repressor Proteins
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Wnt Proteins