Synaptic plasticity in the spinal dorsal horn

Neurosci Res. 2009 Jun;64(2):133-6. doi: 10.1016/j.neures.2009.03.004. Epub 2009 Mar 20.

Abstract

Long-term potentiation (LTP) at synapses in the spinal dorsal horn is thought to be a cellular mechanism for abnormal pain sensitivity. In this article, we review LTP in spinal projection neurons and presynaptic mechanisms of LTP in the spinal dorsal horn revealed by patch-clamp recording and optical imaging with voltage-sensitive dye.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Fluorescent Dyes
  • Fluorometry
  • Long-Term Potentiation*
  • Optical Phenomena
  • Patch-Clamp Techniques
  • Posterior Horn Cells / physiology*
  • Synapses / physiology*

Substances

  • Fluorescent Dyes