Vitek2 system: a reliable tool to detect qnr determinants in Enterobacteriaceae without quinolone resistance-determining region modifications

Stéphane Corvec; Lise Crémet; Alain Reynaud; Didier Lepelletier; Nathalie Caroff

doi:10.1016/j.diagmicrobio.2009.03.026

Vitek2 system: a reliable tool to detect qnr determinants in Enterobacteriaceae without quinolone resistance-determining region modifications

Diagn Microbiol Infect Dis. 2009 Aug;64(4):455-7. doi: 10.1016/j.diagmicrobio.2009.03.026. Epub 2009 May 15.

Authors

Stéphane Corvec¹, Lise Crémet, Alain Reynaud, Didier Lepelletier, Nathalie Caroff

Affiliation

¹ Service de Bactériologie-Hygiène hospitalière, CHU de Nantes, 9 quai Moncousu, 44093 Nantes Cedex 01, France. stephane.corvec@chu-nantes.fr

PMID: 19446979
DOI: 10.1016/j.diagmicrobio.2009.03.026

Abstract

Qnr determinants have now been found worldwide. In 2008, among 6150 Enterobacteriaceae, 12 isolates belonging to different bacterial species showing an unusual quinolone resistance pattern on Vitek2 system were investigated. Of 12, 11 harbored a qnr gene. Without QRDR modifications, qnr genes can be detected based on a Vitek2 resistance phenotype.

MeSH terms

Anti-Bacterial Agents / pharmacology*
DNA Fingerprinting
DNA, Bacterial / genetics
Drug Resistance, Bacterial*
Enterobacteriaceae / drug effects*
Enterobacteriaceae / growth & development*
Humans
Microbial Sensitivity Tests / methods*
Quinolones / pharmacology*

Substances

Anti-Bacterial Agents
DNA, Bacterial
Quinolones