Obesity genes-it's all about the parents!

Cell Metab. 2009 Jun;9(6):487-8. doi: 10.1016/j.cmet.2009.05.008.

Abstract

Maternal inheritance of mutations in the GNAS1 gene is associated with obesity in humans, but the mechanism involved is unknown. In this issue, Chen et al. (2009) have generated mice with brain specific deletion of either the maternal or paternal allele to trace the origin of the phenotype.

Publication types

  • Comment

MeSH terms

  • Alleles
  • Animals
  • Energy Metabolism
  • Female
  • GTP-Binding Protein alpha Subunits, Gs / genetics*
  • GTP-Binding Protein alpha Subunits, Gs / metabolism
  • Leptin / metabolism
  • Male
  • Melanocortins / metabolism
  • Mice
  • Mice, Knockout
  • Mutation
  • Obesity / genetics*
  • Obesity / metabolism
  • Receptor, Melanocortin, Type 4 / deficiency
  • Receptor, Melanocortin, Type 4 / metabolism

Substances

  • Leptin
  • Melanocortins
  • Receptor, Melanocortin, Type 4
  • GTP-Binding Protein alpha Subunits, Gs