Lewis acid-catalyzed diastereoselective hydroarylation of benzylidene malonic esters

J Org Chem. 2009 Jun 19;74(12):4612-4. doi: 10.1021/jo900367g.

Abstract

Herein we report that simple Lewis acids catalyze the hydroarylation of benzylidene malonates with phenols. Ultimately, 3,4-disubstituted dihydrocoumarins are obtained via a hydroarylation-lactonization sequence. Moreover, the dihydrocoumarins are formed with a high degree of diastereoselectivity favoring the trans stereoisomer.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Benzylidene Compounds / chemistry*
  • Catalysis
  • Coumarins / chemical synthesis*
  • Esters / chemistry
  • Malonates / chemistry*
  • Phenols / chemistry
  • Stereoisomerism

Substances

  • Benzylidene Compounds
  • Coumarins
  • Esters
  • Malonates
  • Phenols
  • malonic acid