Novel amphiphilic hyperbranched poly (amine-ester) copolymers nanoparticles as protein drug delivery

Mini Rev Med Chem. 2009 Oct;9(11):1342-56. doi: 10.2174/138955709789878088.

Abstract

Novel amphiphilic protein-loaded hyperbranched poly (amine-ester) copolymers nanoparticles were fabricated by double emulsion (DE) and nanoprecipitation (NP) methods. Encapsulation efficiency (EE) of nanoparticles to Bovine serum albumin (BSA) could reach 97.8% at BSA (0.01 g/ml), internal phase volume (0.5 ml), copolymer weight (50mg), and PVA concentration (4%, w/v) condition.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amines / chemistry
  • Animals
  • Cattle
  • Drug Carriers / chemistry*
  • Drug Delivery Systems
  • Magnetic Resonance Spectroscopy
  • Nanoparticles / chemistry*
  • Polyesters / chemistry
  • Polymers / chemical synthesis
  • Polymers / chemistry*
  • Serum Albumin, Bovine / administration & dosage
  • Serum Albumin, Bovine / chemistry
  • Serum Albumin, Bovine / metabolism
  • Spectrophotometry, Infrared

Substances

  • Amines
  • Drug Carriers
  • Polyesters
  • Polymers
  • Serum Albumin, Bovine
  • poly(lactide)