Abstract
4-hydroxy-isophthalaldehyde acid (1), its alkyl esters (methyl, ethyl, propyl and butyl) and alkyl ethers (propyl, butyl, pentyl and esyl), as well as 6-hydroxy-isophthalaldehyde acid (2) ita alkyl esters (methyl and ethyl), 4-hydroxy-5-iodo-isophthalaldehyde acid (3) and its methyl ester were synthesized and characterized. Antimicrobial and antifungal activity was tested and the LD50 of the most active compound 4 was determined.
MeSH terms
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Animals
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Anti-Bacterial Agents
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Anti-Infective Agents / chemical synthesis*
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Anti-Infective Agents / pharmacology
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Anti-Infective Agents / toxicity
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Fungi / drug effects
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Magnetic Resonance Spectroscopy
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Mice
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Microbial Sensitivity Tests
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Phthalic Acids / chemical synthesis*
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Phthalic Acids / pharmacology
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Phthalic Acids / toxicity
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Spectrophotometry, Infrared
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents
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Phthalic Acids
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4-hydroxyisophthalaldehyde