Preliminary report: No association between TCF7L2 rs7903146 and euglycemic-clamp-derived insulin sensitivity in a mixed-age cohort

Metabolism. 2009 Oct;58(10):1369-71. doi: 10.1016/j.metabol.2009.04.023. Epub 2009 Jul 1.

Abstract

There are conflicting reports about the significance of TCF7L2 single nucleotide polymorphism rs7903146, a single nucleotide polymorphism found to be associated with type 2 diabetes mellitus in several genomewide association studies, and insulin sensitivity. The association of rs7903146 and euglycemic-clamp-derived insulin sensitivity was tested in a cohort of children and their parents. Four hundred seventy whites (from 226 families) and 89 African Americans (from 48 families) were included in the analysis. No significant associations were seen between rs7903146 and insulin sensitivity. Adjusted genotype means were consistent across races and generational subgroups.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adult
  • Aging / physiology
  • Black People
  • Black or African American
  • Child
  • Cohort Studies
  • Female
  • Glucose Clamp Technique*
  • Humans
  • Insulin Resistance / genetics*
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide / genetics*
  • Polymorphism, Single Nucleotide / physiology*
  • Risk Factors
  • TCF Transcription Factors / genetics*
  • Transcription Factor 7-Like 2 Protein
  • White People
  • Young Adult

Substances

  • TCF Transcription Factors
  • TCF7L2 protein, human
  • Transcription Factor 7-Like 2 Protein