Cytotoxic triterpenoids from the rhizomes of Astilbe chinensis

Xing-Fu Cai; Bo-Young Park; Kyung-Seop Ahn; Ok-Kyoung Kwon; Hyeong-Kyu Lee; Sei-Ryang Oh

doi:10.1021/np900028v

Cytotoxic triterpenoids from the rhizomes of Astilbe chinensis

J Nat Prod. 2009 Jul;72(7):1241-4. doi: 10.1021/np900028v.

Authors

Xing-Fu Cai¹, Bo-Young Park, Kyung-Seop Ahn, Ok-Kyoung Kwon, Hyeong-Kyu Lee, Sei-Ryang Oh

Affiliation

¹ Immune Modulator Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Korea.

PMID: 19585998
DOI: 10.1021/np900028v

Abstract

Six new triterpenoids (1-6) with a carboxylic acid functionality at C-27 were isolated from the rhizomes of a Korean native perennial herb, Astilbe chinensis, along with nine known triterpenoids. The structures of 1-6 were elucidated on the basis of spectroscopic data interpretation. All compounds isolated were evaluated for cytotoxic effects against a small panel of human cancer lines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology*
Drug Screening Assays, Antitumor
Humans
Korea
Molecular Structure
Plants, Medicinal / chemistry*
Rhizome / chemistry
Saxifragaceae / chemistry*
Triterpenes / chemistry
Triterpenes / isolation & purification*
Triterpenes / pharmacology*

Substances

Antineoplastic Agents, Phytogenic
Triterpenes