Hydrazine-induced liver toxicity is enhanced by glutathione depletion but is not mediated by oxidative stress in HepG2 cells

Int J Antimicrob Agents. 2009 Oct;34(4):385-6. doi: 10.1016/j.ijantimicag.2009.06.003. Epub 2009 Jul 9.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antitubercular Agents* / metabolism
  • Antitubercular Agents* / toxicity
  • Cell Line, Tumor
  • Cell Survival
  • Glutathione / metabolism*
  • Humans
  • Hydrazines / adverse effects
  • Hydrazines / toxicity*
  • Isoniazid* / metabolism
  • Isoniazid* / toxicity
  • Liver / cytology
  • Liver / pathology*
  • Oxidative Stress*
  • Reactive Oxygen Species / metabolism

Substances

  • Antitubercular Agents
  • Hydrazines
  • Reactive Oxygen Species
  • hydrazine
  • Glutathione
  • Isoniazid