Organocatalysts immobilised onto gold nanoparticles: application in the asymmetric reduction of imines with trichlorosilane

Org Biomol Chem. 2009 May 7;7(9):1878-83. doi: 10.1039/b821391g. Epub 2009 Mar 25.

Abstract

Gold nanoparticles functionalised with a valine-derived formamide have been developed as effective homogenous catalysts for the asymmetric reduction of ketimine 1 with trichlorosilane (< or = 84% ee) in toluene. This methodology both simplifies the recovery of the catalyst and its separation from the product, as the nanoparticles can be readily removed and subsequently recycled by precipitation from the reaction mixture.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Gold / chemistry*
  • Imines / chemistry*
  • Metal Nanoparticles / chemistry*
  • Molecular Structure
  • Oxidation-Reduction
  • Silanes / chemistry*
  • Stereoisomerism
  • Thioctic Acid / chemistry

Substances

  • Imines
  • Silanes
  • Thioctic Acid
  • Gold
  • trichlorosilane