Severe HIV-associated hypertriglyceridaemia treated with rosuvastatin plus omega-3 fatty acids

Int J STD AIDS. 2009 Aug;20(8):580-1. doi: 10.1258/ijsa.2008.008419.

Abstract

Compared with healthy controls, HIV patients already have abnormal lipoprotein concentrations before the initiation of highly active antiretroviral therapy (HAART), which worsen with the therapy. HAART-associated dyslipidaemia features fundamental proatherogenic changes such as increased plasma triglycerides (TGs), increased total cholesterol and low-density lipoprotein cholesterol as well as decreased high-density lipoprotein cholesterol (HDL-C). The current guidelines for managing HIV-associated dyslipidaemia recommend diet and exercise counselling, alteration of HAART regimen or addition of lipid-lowering medications such as statins, fibrates and omega-3 (OM-3) fatty acids. Given that cardiovascular risk significantly increases with elevated lipid levels, selecting a drug to manage dyslipidaemia is particularly important. A case is described of an HIV patient who had severe hypertriglyceridaemia and bad metabolic parameters treated with rosuvastatin and OM-3 fatty acids. So we obtained a more marked reduction of TG levels than has never been described before in the literature, associated with a significant increase in HDL-C levels.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Drug Therapy, Combination
  • Fatty Acids, Omega-3 / administration & dosage*
  • Fluorobenzenes / administration & dosage*
  • HIV Infections / complications*
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage*
  • Hypertriglyceridemia / drug therapy*
  • Male
  • Pyrimidines / administration & dosage*
  • Rosuvastatin Calcium
  • Sulfonamides / administration & dosage*

Substances

  • Fatty Acids, Omega-3
  • Fluorobenzenes
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Pyrimidines
  • Sulfonamides
  • Rosuvastatin Calcium