Abstract
Fear of eye gaze is common in social anxiety disorder (SAD) and may represent an evolutionarily conserved submissive behavior. SAD subjects and healthy volunteers who underwent functional magnetic resonance imaging showed significant differences in neural activity in amygdala, fusiform, insula, anterior cingulate and prefrontal cortex in response to direct versus averted gaze. Neural response to direct gaze may identify brain regions important in the pathophysiology of SAD.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Anxiety Disorders* / complications
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Anxiety Disorders* / pathology
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Anxiety Disorders* / psychology
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Brain / blood supply
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Brain / pathology*
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Brain Mapping*
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Dominance-Subordination*
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Fixation, Ocular / physiology*
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Humans
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Image Processing, Computer-Assisted / methods
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Magnetic Resonance Imaging / methods
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Neural Pathways / blood supply
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Neural Pathways / pathology
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Oxygen / blood
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Social Behavior Disorders* / complications
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Social Behavior Disorders* / pathology
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Social Behavior Disorders* / psychology