Ars2 and the Cap-Binding Complex Team up for Silencing

Anne F Nielsen; Jiradet Gloggnitzer; Javier Martinez

doi:10.1016/j.cell.2009.07.009

Ars2 and the Cap-Binding Complex Team up for Silencing

Cell. 2009 Jul 23;138(2):224-6. doi: 10.1016/j.cell.2009.07.009.

Authors

Anne F Nielsen¹, Jiradet Gloggnitzer, Javier Martinez

Affiliation

¹ Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr. Bohr-Gasse 3, 1030 Vienna, Austria.

PMID: 19632172
DOI: 10.1016/j.cell.2009.07.009

Abstract

In this issue, Sabin et al. (2009) and Gruber et al. (2009) reveal the protein Ars2 as a versatile regulator of RNA silencing. They show that Ars2 stimulates microRNA processing, contributes to antiviral resistance in flies, and is important for cell proliferation in mammals.

Publication types

Comment

MeSH terms

Animals
Cell Survival
Humans
Nuclear Proteins / immunology
Nuclear Proteins / metabolism*
RNA Cap-Binding Proteins / metabolism*
RNA Interference

Substances

Nuclear Proteins
RNA Cap-Binding Proteins