Fatal Chromobacterium violaceum septicaemia in northern Laos, a modified oxidase test and post-mortem forensic family G6PD analysis

Ann Clin Microbiol Antimicrob. 2009 Jul 29:8:24. doi: 10.1186/1476-0711-8-24.

Abstract

Background: Chromobacterium violaceum is a Gram negative facultative anaerobic bacillus, found in soil and stagnant water, that usually has a violet pigmented appearance on agar culture. It is rarely described as a human pathogen, mostly from tropical and subtropical areas.

Case presentation: A 53 year-old farmer died with Chromobacterium violaceum septicemia in Laos. A modified oxidase method was used to demonstrate that this violacious organism was oxidase positive. Forensic analysis of the glucose-6-phosphate dehydrogenase genotypes of his family suggest that the deceased patient did not have this possible predisposing condition.

Conclusion: C. violaceum infection should be included in the differential diagnosis in patients presenting with community-acquired septicaemia in tropical and subtropical areas. The apparently neglected but simple modified oxidase test may be useful in the oxidase assessment of other violet-pigmented organisms or of those growing on violet coloured agar.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Proteins / metabolism*
  • Chromobacterium / enzymology
  • Chromobacterium / genetics
  • Chromobacterium / isolation & purification*
  • Fatal Outcome
  • Female
  • Glucosephosphate Dehydrogenase / genetics*
  • Glucosephosphate Dehydrogenase / metabolism
  • Humans
  • Laos
  • Male
  • Middle Aged
  • Mutation
  • Oxidoreductases / metabolism*
  • Sepsis / diagnosis*
  • Sepsis / microbiology*

Substances

  • Bacterial Proteins
  • Oxidoreductases
  • Glucosephosphate Dehydrogenase