Similar early gene responses to ligand-activated EGFR and neu tyrosine kinases in NIH3T3 cells

Oncogene. 1990 Apr;5(4):615-8.

Abstract

We have compared the responses of serum-inducible immediate early genes to ligand activation of the epidermal growth factor receptor (EGFR) or a hybrid EGFR/neu receptor containing the intracellular domain of the neu proto-oncogene. Few differences in mRNA induction kinetics were found, emphasizing the functional similarity of these structurally related tyrosine kinases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Transformation, Neoplastic
  • Cells, Cultured
  • Chimera
  • Epidermal Growth Factor / pharmacology*
  • ErbB Receptors / genetics*
  • Gene Expression / drug effects*
  • Kinetics
  • Mice
  • Protein-Tyrosine Kinases / genetics
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogenes / drug effects*
  • RNA, Messenger / genetics
  • Receptor, ErbB-2
  • Transcription, Genetic

Substances

  • Proto-Oncogene Proteins
  • RNA, Messenger
  • Epidermal Growth Factor
  • ErbB Receptors
  • Protein-Tyrosine Kinases
  • Receptor, ErbB-2