Mobilization of progenitor cells into the blood by immobilized granulocytic colony-stimulating factor
Bull Exp Biol Med. 2009 Apr;147(4):499-502.
doi: 10.1007/s10517-009-0550-y.
[Article in
English,
Russian]
Authors
A M Dygai
1
, E I Vereshchagin, G N Zyuz'kov, V V Zhdanov, P G Madonov, E V Simanina, L A Stavrova, E V Udut, T Yu Khrichkova, L A Miroshnichenko, M Yu Minakova, N N Ermakova, T V Firsova
Affiliation
- 1 Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. mmu@pharm.tsu.ru
Abstract
The effects of granulocytic CSF immobilized on polyethylenoxide by nanotechnology on the bone marrow and circulating pools of mesenchymal and hemopoietic precursors were studied. Immobilized granulocytic CSF caused the release of progenitor cells of different classes into the blood. The effect of injected immobilized granulocytic CSF was superior to that of nonconjugated granulocytic CSF. Specific activity of oral immobilized granulocytic CSF after oral administration was demonstrated.
MeSH terms
-
Animals
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Blood Physiological Phenomena / drug effects*
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Bone Marrow / drug effects
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Granulocyte-Macrophage Colony-Stimulating Factor / administration & dosage
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Granulocyte-Macrophage Colony-Stimulating Factor / pharmacology*
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Growth Substances / administration & dosage
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Growth Substances / pharmacology*
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Leukocytes, Mononuclear / drug effects
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Leukocytes, Mononuclear / physiology
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Mesenchymal Stem Cells / drug effects
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Mesenchymal Stem Cells / physiology
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Mice
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Mice, Inbred CBA
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Stem Cells / drug effects*
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Stem Cells / physiology*
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Time Factors
Substances
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Growth Substances
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Granulocyte-Macrophage Colony-Stimulating Factor