Exogenous leptin administration decreases sperm count and increases the fraction of abnormal sperm in adult rats

Mohd Nizam Haron; Urban J A D'Souza; Hasnan Jaafar; Rahimah Zakaria; Harbindar Jeet Singh

doi:10.1016/j.fertnstert.2009.07.995

Exogenous leptin administration decreases sperm count and increases the fraction of abnormal sperm in adult rats

Fertil Steril. 2010 Jan;93(1):322-4. doi: 10.1016/j.fertnstert.2009.07.995. Epub 2009 Aug 25.

Authors

Mohd Nizam Haron¹, Urban J A D'Souza, Hasnan Jaafar, Rahimah Zakaria, Harbindar Jeet Singh

Affiliation

¹ Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia.

PMID: 19709655
DOI: 10.1016/j.fertnstert.2009.07.995

Abstract

Daily intraperitoneal injection of 5-30 microg/kg body weight of leptin for 42 days to adult rats decreases sperm count and increases the fraction of abnormal sperm.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Injections, Intraperitoneal
Leptin / administration & dosage*
Male
Rats
Rats, Sprague-Dawley
Recombinant Proteins / administration & dosage
Seminiferous Tubules / drug effects
Seminiferous Tubules / pathology
Sperm Count*
Spermatozoa / drug effects*
Spermatozoa / pathology
Time Factors

Substances

Leptin
Recombinant Proteins