The radiologic investigation of asymptomatic hematuria has changed significantly due to the introduction of new imaging modalities and innovative techniques, such as computed tomography urogaphy, which allows a comprehensive evaluation of the entire urinary tract in a single study. There is still a role for "older" imaging modalities, such as intravenous urography and ultrasound, and their use is still advocated in younger patients with a lower risk of malignancy to minimize radiation dose. Combined modality imaging can also be useful for characterization of lesions. Guidelines have recently been published for the radiologic investigation of hematuria; these are discussed in this article.