Science to practice: can an enzyme-sensitive MR contrast agent be used to image inflammation in aneurysms?

Radiology. 2009 Sep;252(3):627-8. doi: 10.1148/radiol.2523090736.

Abstract

DeLeo et al have demonstrated in an animal model that inflammation associated with aneurysms can be evaluated noninvasively with magnetic resonance (MR) imaging and use of activatable contrast agents.

Publication types

  • Comment

MeSH terms

  • Animals
  • Carotid Artery Diseases / enzymology*
  • Carotid Artery Diseases / pathology*
  • Carotid Artery, Common / enzymology*
  • Carotid Artery, Common / pathology*
  • Cerebral Angiography
  • Contrast Media / chemistry*
  • Contrast Media / pharmacology
  • Dilatation, Pathologic / enzymology
  • Dilatation, Pathologic / pathology
  • Disease Models, Animal
  • Gadolinium DTPA / chemistry*
  • Gadolinium DTPA / pharmacology
  • Image Enhancement / methods
  • Inflammation / enzymology
  • Inflammation / pathology
  • Intracranial Aneurysm / enzymology*
  • Intracranial Aneurysm / pathology
  • Magnetic Resonance Imaging / methods*
  • Peroxidase / metabolism*
  • Rabbits

Substances

  • Contrast Media
  • Peroxidase
  • Gadolinium DTPA