The effects of clozapine on rat mast cells are different from those of benzodiazepines

Gen Pharmacol. 1990;21(4):559-61. doi: 10.1016/0306-3623(90)90715-x.

Abstract

1. Clozapine caused dose-dependent inhibition of the release of [14C]serotonin and 45Ca uptake by purified rat peritoneal mast cells activated by concanavalin A, which is similar to the effect of benzodiazepines. 2. However, it had little ability to displace [3H]diazepam binding to mast cells.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Anxiety Agents / pharmacology*
  • Binding, Competitive / drug effects
  • Calcimycin / pharmacology
  • Calcium / metabolism
  • Calcium Radioisotopes
  • Clozapine / pharmacology*
  • Concanavalin A / pharmacology
  • Diazepam / metabolism
  • Dibenzazepines / pharmacology*
  • In Vitro Techniques
  • Male
  • Mast Cells / drug effects*
  • Rats
  • Rats, Inbred Strains
  • Serotonin / metabolism

Substances

  • Anti-Anxiety Agents
  • Calcium Radioisotopes
  • Dibenzazepines
  • Concanavalin A
  • Serotonin
  • Calcimycin
  • Clozapine
  • Diazepam
  • Calcium