Synthesis of phthalocyanines-ALA conjugates: water-soluble compounds with low aggregation

J Org Chem. 2009 Oct 16;74(20):7962-5. doi: 10.1021/jo901633a.

Abstract

Syntheses of two water-soluble phthalocyanines (Pc) containing 5-aminolevulinic acid (ALA) linked to the core structure are described. These compounds were prepared by using original functionalizations, and they present remarkable structural and photophysical features, indicating that they could be applied to photodynamic therapy (PDT).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aminolevulinic Acid / chemical synthesis*
  • Aminolevulinic Acid / chemistry
  • Indoles / chemical synthesis*
  • Indoles / chemistry
  • Isoindoles
  • Molecular Structure
  • Solubility
  • Water / chemistry*

Substances

  • Indoles
  • Isoindoles
  • Water
  • Aminolevulinic Acid
  • phthalocyanine