Abstract
A novel PET radiotracer, [18F]-1-deoxy-1-fluoro-scyllo-inositol, was synthesized via a one-pot reaction in 16 +/- 3% uncorrected radiochemical yield within 80 minutes; although this compound revealed low brain penetration it shows promise in rodent tumour models for breast cancer imaging.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Cell Line, Tumor
-
Fluorine Radioisotopes / chemistry
-
Humans
-
Inositol / analogs & derivatives*
-
Inositol / chemical synthesis
-
Inositol / chemistry
-
Male
-
Mice
-
Positron-Emission Tomography
-
Radiopharmaceuticals / chemical synthesis*
-
Radiopharmaceuticals / chemistry
-
Rats
-
Rats, Sprague-Dawley
-
Stereoisomerism
-
Transplantation, Heterologous
Substances
-
(18F)-1-deoxy-1-fluoro-scyllo-inositol
-
Fluorine Radioisotopes
-
Radiopharmaceuticals
-
Inositol