Bypassing stereoselectivity in the early steps of alkaloid biosynthesis

Org Biomol Chem. 2009 Oct 21;7(20):4166-8. doi: 10.1039/b916027m. Epub 2009 Aug 13.

Abstract

Total synthesis of glycosylated seco-iridoid stereoisomers allows the identification and bypassing of the stereoselectivity of early steps in monoterpene indole alkaloid biosynthesis.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Alkaloids / biosynthesis*
  • Alkaloids / chemistry*
  • Catharanthus / enzymology
  • Glucosidases / metabolism
  • Glycosylation
  • Kinetics
  • Stereoisomerism
  • Substrate Specificity

Substances

  • Alkaloids
  • Glucosidases
  • strictosidine glucosidase