Assessment of Parkinson disease manifestations

Curr Protoc Neurosci. 2009 Oct:Chapter 10:Unit10.1. doi: 10.1002/0471142301.ns1001s49.

Abstract

Parkinson disease (PD) is a progressive neurologic condition that causes motor and nonmotor manifestations. Treatment provides symptomatic benefit but no current treatment has been proven to slow disease progression. Research studies of PD require a means of rating the severity of disease by measurement of motor manifestations, assessment of ability to perform daily functional activities, and symptomatic response to medication. The most common rating scales are the Unified Parkinson Disease Rating Scale (UPDRS), Hoehn and Yahr staging, and the Schwab and England rating of activities of daily living. Each of these rating scales are described, including detailed instructions on how to implement these ratings. Although these are the most widely applied rating scales of PD, there are still substantial limitations to these scales that must be considered when using them for research. Finally, some common applications of these scales are described.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activities of Daily Living
  • Antiparkinson Agents / pharmacology
  • Disability Evaluation*
  • Humans
  • Movement Disorders / diagnosis
  • Movement Disorders / drug therapy
  • Movement Disorders / physiopathology
  • Neurologic Examination / methods
  • Outcome Assessment, Health Care / methods*
  • Parkinson Disease / diagnosis*
  • Parkinson Disease / drug therapy
  • Parkinson Disease / physiopathology*
  • Physical Examination / methods
  • Severity of Illness Index

Substances

  • Antiparkinson Agents