The purpose of this study was to compare the accuracy, velocity, and kinematics of throws with the dominant and nondominant arms in experienced handball players. Significant differences in throwing accuracy and ball velocity were found: decreased maximal velocities of the major joint movements and especially decreased internal rotation velocity of the shoulder. Timing differences in the onset of some joint movements, which resulted in an altered throwing pattern, could explain differences in the throwing velocity. Lower ball velocity was compensated by the increased ball release height, which was caused by an increased shoulder abduction and trunk tilt sideways angle at ball release.